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Biographical Information:

Anastacia studies splicing and more specifically, the role of RNA structure at splice sites. She moved to North Carolina from Washington State and joined the lab in 2021 as a Bioinformatics and Computational Biology graduate student. Since then, she has been able to learn a lot about big data analysis, genomics, structure analysis, cloud computing, and, of course, become a master of troubleshooting!

A fun fact about Anastacia: She has visited 41 states and lived in 5. “Couldn’t pick a favorite, all have their charms!”

Publications:

Aaztli Coria, Anastacia Wienecke, Michael L Knight, Daniel DesirĂ², Alain Laederach, Alexander Borodavka, Rotavirus RNA chaperone mediates global transcriptome-wide increase in RNA backbone flexibility, Nucleic Acids Research, Volume 50, Issue 17, 23 September 2022, Pages 10078–10092, https://doi.org/10.1093/nar/gkac738

Wienecke A, Laederach A. A novel algorithm for ranking RNA structure candidates. Biophys J. 2022;121(1):7-10. doi:10.1016/j.bpj.2021.12.004

Anastacia N Wienecke, Margaret L Barry, Daniel A Pollard, Natural variation in codon bias and mRNA folding strength interact synergistically to modify protein expression in Saccharomyces cerevisiae, Genetics, Volume 224, Issue 4, August 2023, iyad113, https://doi.org/10.1093/genetics/iyad113